| 1. Ronde | 13.09.2020 | Deportivo Alavés | - | Real Betis | 0:1 | ||||
| 2. Ronde | 20.09.2020 | Real Betis | - | Real Valladolid | 2:0 | ||||
| 3. Ronde | 26.09.2020 | Real Betis | - | Real Madrid | 2:3 |  |
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| 4. Ronde | 29.09.2020 | Getafe CF | - | Real Betis | 3:0 | ||||
| 5. Ronde | 03.10.2020 | Valencia CF | - | Real Betis | 0:2 | |
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| 6. Ronde | 18.10.2020 | Real Betis | - | Real Sociedad | 0:3 | |
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| 7. Ronde | 24.10.2020 | Atlético Madrid | - | Real Betis | 2:0 | ||||
| 8. Ronde | 01.11.2020 | Real Betis | - | Elche CF | 3:1 | ||||
| 9. Ronde | 07.11.2020 | FC Barcelona | - | Real Betis | 5:2 | ||||
| 11. Ronde | 30.11.2020 | Real Betis | - | SD Eibar | 0:2 | ||||
| 12. Ronde | 06.12.2020 | CA Osasuna | - | Real Betis | 0:2 | ||||
| 13. Ronde | 13.12.2020 | Real Betis | - | Villarreal CF | 1:1 | ||||
| 14. Ronde | 20.12.2020 | Granada CF | - | Real Betis | 2:0 | ||||
| 30. Ronde | 11.04.2021 | Real Betis | - | Atlético Madrid | 1:1 | ||||
| 31. Ronde | 21.04.2021 | Real Betis | - | Athletic Club | 0:0 | ||||
| 35. Ronde | 10.05.2021 | Real Betis | - | Granada CF | 2:1 | ||||
| 36. Ronde | 13.05.2021 | SD Eibar | - | Real Betis | 1:1 | ||||
| 37. Ronde | 16.05.2021 | Real Betis | - | SD Huesca | 1:0 | ||||
| 38. Ronde | 22.05.2021 | Celta de Vigo | - | Real Betis | 2:3 |
Spanje
