| 2. Ronde | 12.09.2021 | Atlético Mancha Real | - | CS Puertollano CF | 2:0 | ||||
| 6. Ronde | 10.10.2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 |  |
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| 8. Ronde | 24.10.2021 | Recreativo Granada | - | CS Puertollano CF | 2:1 | ||||
| 13. Ronde | 28.11.2021 | CS Puertollano CF | - | Real Murcia | 1:2 | ||||
| 14. Ronde | 05.12.2021 | UD Alzira | - | CS Puertollano CF | 2:1 |
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