| 2. Ronde | 05.09.2021 | Real Valladolid B | - | Real Unión | 0:2 | ||||
| 3. Ronde | 11.09.2021 | Racing Ferrol | - | Real Valladolid B | 2:1 | ||||
| 6. Ronde | 02.10.2021 | Real Valladolid B | - | Unionistas CF | 0:0 | ||||
| 8. Ronde | 17.10.2021 | Real Valladolid B | - | Athletic Club B | 3:1 | ||||
| 10. Ronde | 29.10.2021 | CF Talavera | - | Real Valladolid B | 0:2 | ||||
| 12. Ronde | 14.11.2021 | Celta de Vigo B | - | Real Valladolid B | 3:0 | ||||
| 15. Ronde | 05.12.2021 | Real Valladolid B | - | Racing Santander | 3:0 | ||||
| 18. Ronde | 08.01.2022 | CD Badajoz | - | Real Valladolid B | 1:2 | ||||
| 19. Ronde | 22.01.2022 | Real Valladolid B | - | CD Tudelano | 0:2 | ||||
| 24. Ronde | 20.02.2022 | Real Valladolid B | - | Racing Ferrol | 1:2 | ||||
| 21. Ronde | 02.03.2022 | Real Unión | - | Real Valladolid B | 2:1 | ||||
| 26. Ronde | 06.03.2022 | Real Valladolid B | - | UD Logroñés | 0:2 | ||||
| 31. Ronde | 10.04.2022 | Real Valladolid B | - | SD Logroñés | 2:0 | ||||
| 34. Ronde | 01.05.2022 | UD SS Reyes | - | Real Valladolid B | 1:1 | ||||
| 37. Ronde | 21.05.2022 | Real Valladolid B | - | Deportivo La Coruña | 0:4 | ||||
| 38. Ronde | 28.05.2022 | Zamora CF | - | Real Valladolid B | 2:0 |
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