| 8. Ronde | 24.10.2021 | UD Alzira | - | Atlético Mancha Real | 0:0 | ||||
| 12. Ronde | 21.11.2021 | CD El Ejido 2012 | - | Atlético Mancha Real | 0:1 |  |
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| 13. Ronde | 28.11.2021 | Atlético Mancha Real | - | CF La Nucía | 0:3 | ||||
| 16. Ronde | 19.12.2021 | Real Murcia | - | Atlético Mancha Real | 1:0 | ||||
| 21. Ronde | 13.02.2022 | Atlético Mancha Real | - | CD Marchamalo | 0:2 | ||||
| 22. Ronde | 20.02.2022 | Recreativo Granada | - | Atlético Mancha Real | 3:0 | ||||
| 28. Ronde | 02.04.2022 | Levante UD B | - | Atlético Mancha Real | 1:1 | |
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| 32. Ronde | 01.05.2022 | Hércules CF | - | Atlético Mancha Real | 3:1 |
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