| 8. Ronde | 17.09.2021 | Spartak Trnava | - | ŠKF Sereď | 2:0 | ||||
| 9. Ronde | 26.09.2021 | FC DAC 1904 | - | Spartak Trnava | 0:3 | ||||
| 10. Ronde | 03.10.2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
| 11. Ronde | 17.10.2021 | Spartak Trnava | - | Slovan Bratislava | 0:3 Toeg. | ||||
| 12. Ronde | 23.10.2021 | FK Pohronie | - | Spartak Trnava | 0:2 | ||||
| 13. Ronde | 29.10.2021 | Spartak Trnava | - | FK Senica | 2:1 | ||||
| 14. Ronde | 07.11.2021 | Tatran Liptovský Mikuláš | - | Spartak Trnava | 0:2 |  |
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| 15. Ronde | 20.11.2021 | Zlaté Moravce | - | Spartak Trnava | 0:0 | |
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| 16. Ronde | 28.11.2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Ronde | 05.12.2021 | MŠK Žilina | - | Spartak Trnava | 0:1 | ||||
| 18. Ronde | 10.12.2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | |
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| 19. Ronde | 18.12.2021 | ŠKF Sereď | - | Spartak Trnava | 0:1 | ||||
| 20. Ronde | 13.02.2022 | Spartak Trnava | - | FC DAC 1904 | 1:1 | |
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| 22. Ronde | 26.02.2022 | Slovan Bratislava | - | Spartak Trnava | 0:0 | |
Slowakije
