| 5. Ronde | 12.02.2022 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | ||||
| 6. Ronde | 18.02.2022 | FC Juárez [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 8. Ronde | 02.03.2022 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 9. Ronde | 05.03.2022 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 10. Ronde | 12.03.2022 | Santos Laguna [U20] | - | Club Tijuana [U20] | 4:2 | ||||
| 11. Ronde | 18.03.2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 13. Ronde | 26.03.2022 | CF Monterrey [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 12. Ronde | 03.04.2022 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:0 | ||||
| 15. Ronde | 19.04.2022 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 16. Ronde | 24.04.2022 | Santos Laguna [U20] | - | Club León [U20] | 0:3 |
Mexico