| 13. Ronde | 16.10.2021 | CF América [U16] | - | Club Tijuana [U16] | 4:2 | ||||
| 14. Ronde | 23.10.2021 | Club Tijuana [U16] | - | CF Pachuca [U16] | 0:1 | ||||
| 15. Ronde | 30.10.2021 | Club Tijuana [U16] | - | Gallos Blancos [U16] | 3:2 | ||||
| 16. Ronde | 06.11.2021 | FC Juárez [U16] | - | Club Tijuana [U16] | 1:3 | ||||
| 17. Ronde | 13.11.2021 | Pumas UNAM [U16] | - | Club Tijuana [U16] | 0:0 |  |
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| 18. Ronde | 20.11.2021 | Club Tijuana [U16] | - | Cruz Azul [U16] | 0:0 | |
Mexico