| 1. Ronde | 28.08.2021 | SD Logroñés | - | Real Valladolid B | 1:1 | ||||
| 3. Ronde | 11.09.2021 | Racing Ferrol | - | Real Valladolid B | 2:1 | ||||
| 5. Ronde | 25.09.2021 | Cultural Leonesa | - | Real Valladolid B | 4:2 |  |
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| 6. Ronde | 02.10.2021 | Real Valladolid B | - | Unionistas CF | 0:0 | ||||
| 9. Ronde | 23.10.2021 | Real Valladolid B | - | Rayo Majadahonda | 0:1 | ||||
| 11. Ronde | 06.11.2021 | Real Valladolid B | - | CD Calahorra | 1:1 |  |
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| 12. Ronde | 14.11.2021 | Celta de Vigo B | - | Real Valladolid B | 3:0 | |
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| 13. Ronde | 20.11.2021 | Real Valladolid B | - | Inter de Madrid | 2:2 | ||||
| 20. Ronde | 26.01.2022 | Rayo Majadahonda | - | Real Valladolid B | 3:1 | |
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| 22. Ronde | 05.02.2022 | Real Valladolid B | - | Celta de Vigo B | 1:3 | |
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| 23. Ronde | 12.02.2022 | Inter de Madrid | - | Real Valladolid B | 2:2 | ||||
| 24. Ronde | 20.02.2022 | Real Valladolid B | - | Racing Ferrol | 1:2 | ||||
| 28. Ronde | 20.03.2022 | Unionistas CF | - | Real Valladolid B | 0:0 | ||||
| 30. Ronde | 02.04.2022 | CD Tudelano | - | Real Valladolid B | 1:2 | ||||
| 34. Ronde | 01.05.2022 | UD SS Reyes | - | Real Valladolid B | 1:1 | |
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| 38. Ronde | 28.05.2022 | Zamora CF | - | Real Valladolid B | 2:0 |
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