| 1. Ronde | 05.09.2021 | CF La Nucía | - | Mar Menor CF | 1:0 | ||||
| 2. Ronde | 12.09.2021 | Mar Menor CF | - | CD Eldense | 1:1 | ||||
| 3. Ronde | 18.09.2021 | Hércules CF | - | Mar Menor CF | 2:1 |  |
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| 4. Ronde | 26.09.2021 | Mar Menor CF | - | Real Murcia | 1:0 | ||||
| 5. Ronde | 03.10.2021 | UD Melilla | - | Mar Menor CF | 2:3 | |
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| 7. Ronde | 17.10.2021 | Atlético Mancha Real | - | Mar Menor CF | 1:2 | |
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| 8. Ronde | 24.10.2021 | Mar Menor CF | - | CD Toledo | 2:0 |
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