| 1. Ronde | 18.09.2021 | Club Necaxa [] | - | Santos Laguna [] | 4:0 | ||||
| 2. Ronde | 25.09.2021 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 | ||||
| 4. Ronde | 09.10.2021 | Mazatlán FC [] | - | Santos Laguna [] | 0:2 | ||||
| 5. Ronde | 16.10.2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 | ||||
| 10. Ronde | 20.11.2021 | Club León [] | - | Santos Laguna [] | 4:2 |
Mexico