| 1. Ronde | 07.02.2021 | Club Olimpia | - | Libertad | 0:1 |  |
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| 4. Ronde | 22.02.2021 | Club Nacional | - | Libertad | 0:3 |  |
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| 2. Ronde | 24.02.2021 | Guaireña FC | - | Libertad | 1:0 | ||||
| 5. Ronde | 02.03.2021 | Libertad | - | River Plate | 2:1 | ||||
| 11. Ronde | 12.04.2021 | Libertad | - | Guaireña FC | 2:1 | ||||
| 17. Ronde | 22.05.2021 | Libertad | - | Sol de América | 1:2 | ||||
| 18. Ronde | 29.05.2021 | Sportivo Luqueño | - | Libertad | 1:3 |
Paraguay