| 1. Ronde | 11.09.2021 | Panetolikos | - | Asteras Tripolis | 0:0 |  |
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| 2. Ronde | 19.09.2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 4. Ronde | 26.09.2021 | Asteras Tripolis | - | Olympiakos | 0:2 | ||||
| 5. Ronde | 02.10.2021 | Volos NFC | - | Asteras Tripolis | 2:1 | ||||
| 7. Ronde | 23.10.2021 | Asteras Tripolis | - | Panathinaikos | 2:1 | ||||
| 8. Ronde | 31.10.2021 | PAS Giannina | - | Asteras Tripolis | 1:1 | ||||
| 9. Ronde | 07.11.2021 | Asteras Tripolis | - | Lamia | 0:1 | ||||
| 10. Ronde | 20.11.2021 | Ionikos Nikea | - | Asteras Tripolis | 1:1 | ||||
| 11. Ronde | 27.11.2021 | Asteras Tripolis | - | Atromitos | 6:2 | ||||
| 12. Ronde | 05.12.2021 | Aris Saloniki | - | Asteras Tripolis | 1:0 | |
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| 14. Ronde | 14.12.2021 | Asteras Tripolis | - | Panetolikos | 1:0 | ||||
| 16. Ronde | 04.01.2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
| 18. Ronde | 15.01.2022 | Asteras Tripolis | - | Volos NFC | 1:0 | ||||
| 20. Ronde | 29.01.2022 | Panathinaikos | - | Asteras Tripolis | 0:1 | ||||
| 24. Ronde | 19.02.2022 | Atromitos | - | Asteras Tripolis | 2:0 | |
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| 22. Ronde | 23.02.2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 25. Ronde | 26.02.2022 | Asteras Tripolis | - | Aris Saloniki | 0:2 | |
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| 26. Ronde | 06.03.2022 | AEK Athene | - | Asteras Tripolis | 2:1 | |
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