| 1. Ronde | 05.09.2021 | CF La Nucía | - | Mar Menor CF | 1:0 | ||||
| 2. Ronde | 12.09.2021 | Mar Menor CF | - | CD Eldense | 1:1 |  |
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| 3. Ronde | 18.09.2021 | Hércules CF | - | Mar Menor CF | 2:1 |  |
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| 4. Ronde | 26.09.2021 | Mar Menor CF | - | Real Murcia | 1:0 | ||||
| 9. Ronde | 31.10.2021 | CD Marchamalo | - | Mar Menor CF | 2:0 | ||||
| 10. Ronde | 07.11.2021 | Mar Menor CF | - | Recreativo Granada | 0:1 |  |
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| 12. Ronde | 21.11.2021 | Mar Menor CF | - | CS Puertollano CF | 1:0 | ||||
| 13. Ronde | 28.11.2021 | Mar Menor CF | - | UD Alzira | 1:0 | ||||
| 14. Ronde | 05.12.2021 | UD Socuéllamos | - | Mar Menor CF | 2:2 | ||||
| 15. Ronde | 12.12.2021 | Mar Menor CF | - | CA Pulpileño | 4:0 | ||||
| 16. Ronde | 19.12.2021 | Levante UD B | - | Mar Menor CF | 1:1 | |
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Spanje