| 5. Ronde | 03.10.2021 | UD San Fernando | - | CD San Roque de Lepe | 0:0 | ||||
| 6. Ronde | 10.10.2021 | Córdoba CF | - | UD San Fernando | 4:1 | ||||
| 7. Ronde | 17.10.2021 | UD San Fernando | - | CP Cacereño | 1:1 | ||||
| 8. Ronde | 24.10.2021 | CF Villanovense | - | UD San Fernando | 2:0 | ||||
| 9. Ronde | 31.10.2021 | UD San Fernando | - | Mérida AD | 0:1 |  |
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| 10. Ronde | 07.11.2021 | UD Las Palmas B | - | UD San Fernando | 1:0 | ||||
| 11. Ronde | 14.11.2021 | UD San Fernando | - | CF Panadería Pulido | 1:0 | |
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| 12. Ronde | 21.11.2021 | AD Ceuta FC | - | UD San Fernando | 1:0 | ||||
| 13. Ronde | 28.11.2021 | UD San Fernando | - | Vélez CF | 0:0 | ||||
| 14. Ronde | 05.12.2021 | Xerez DFC | - | UD San Fernando | 1:0 | ||||
| 15. Ronde | 12.12.2021 | UD San Fernando | - | Cádiz CF B | 0:0 | ||||
| 16. Ronde | 19.12.2021 | CD Coria | - | UD San Fernando | 2:2 | ||||
| 17. Ronde | 09.01.2022 | UD San Fernando | - | Don Benito | 1:3 | ||||
| 19. Ronde | 30.01.2022 | UD Montijo | - | UD San Fernando | 2:0 |
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