| 1. Ronde | 05.09.2021 | CD Cayón | - | AD San Juan | 0:2 | ||||
| 4. Ronde | 25.09.2021 | AD San Juan | - | CA Osasuna B | 0:2 | ||||
| 5. Ronde | 03.10.2021 | SD Gernika | - | AD San Juan | 1:1 | ||||
| 8. Ronde | 23.10.2021 | AD San Juan | - | CD Izarra | 0:1 | ||||
| 9. Ronde | 30.10.2021 | CD Tropezón | - | AD San Juan | 3:4 | ||||
| 10. Ronde | 06.11.2021 | AD San Juan | - | CD Laredo | 2:0 | ||||
| 12. Ronde | 20.11.2021 | AD San Juan | - | Náxara CD | 2:1 | ||||
| 14. Ronde | 05.12.2021 | Burgos Promesas | - | AD San Juan | 1:1 | ||||
| 16. Ronde | 18.12.2021 | CF Ardoi | - | AD San Juan | 0:0 | ||||
| 20. Ronde | 05.02.2022 | AD San Juan | - | Sestao River | 0:2 | ||||
| 21. Ronde | 13.02.2022 | CA Osasuna B | - | AD San Juan | 3:4 |  |
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| 24. Ronde | 05.03.2022 | AD San Juan | - | UD Mutilvera | 2:1 | ||||
| 26. Ronde | 19.03.2022 | AD San Juan | - | CD Tropezón | 4:3 | ||||
| 27. Ronde | 26.03.2022 | CD Laredo | - | AD San Juan | 0:1 | |
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| 33. Ronde | 08.05.2022 | AD San Juan | - | CF Ardoi | 2:0 | ||||
| 34. Ronde | 15.05.2022 | Peña Sport FC | - | AD San Juan | 0:4 |
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