| 1. Ronde | 16.07.2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Ronde | 23.07.2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 4. Ronde | 30.07.2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 5. Ronde | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Ronde | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Ronde | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 16. Ronde | 14.10.2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 20. Ronde | 05.11.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 22. Ronde | 24.11.2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Ronde | 30.11.2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Ronde | 06.12.2021 | Newell's Old Boys II | - | Banfield II | 2:0 |
Argentinië