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| 22.11.2021 | 13:00 | Arsenal de Sarandí II | - | Unión de Santa Fe II | 0:0 (0:0) | |
| 23.11.2021 | 13:00 | Aldosivi II | - | San Lorenzo II | 1:0 (0:0) | |
| 13:00 | Huracán II | - | Patronato de Paraná II | 1:0 (1:0) | ||
| 13:00 | Lanús II | - | Platense II | 5:5 (4:3) | ||
| 13:00 | Godoy Cruz II | - | Estudiantes II | 0:0 (0:0) | ||
| 13:00 | Gimnasia de La Plata II | - | Talleres de Córdoba II | 1:0 (1:0) | ||
| 13:00 | River Plate II | - | Racing Club II | 1:2 (0:1) | ||
| 21:00 | Sarmiento de Junín II | - | Banfield II | 3:1 (2:0) | ||
| 24.11.2021 | 13:00 | Atlético Tucumán II | - | Defensa y Justicia II | 4:1 (1:0) | |
| 13:00 | Colón de Santa Fe II | - | Rosario Central II | 1:1 (0:0) | ||
| 13:00 | Independiente II | - | Boca Juniors II | 0:0 (0:0) | ||
| 13:00 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 (1:0) | ||
| 25.11.2021 | 13:00 | Vélez Sarsfield II | - | Argentinos Juniors II | 1:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 22 | 12 | 7 | 3 | 53:22 | 31 | 43 |
| 2 |
|
Argentinos Juniors II | 22 | 11 | 6 | 5 | 29:20 | 9 | 39 |
| 3 |
|
Estudiantes II | 22 | 10 | 8 | 4 | 35:25 | 10 | 38 |
| 4 |
|
Colón de Santa Fe II | 22 | 10 | 8 | 4 | 24:16 | 8 | 38 |
| 5 |
|
Rosario Central II | 22 | 10 | 6 | 6 | 42:28 | 14 | 36 |
| 6 |
|
Gimnasia de La Plata II | 22 | 10 | 6 | 6 | 33:28 | 5 | 36 |
| 7 |
|
Lanús II | 22 | 10 | 5 | 7 | 33:25 | 8 | 35 |
| 8 |
|
Platense II | 22 | 9 | 6 | 7 | 36:30 | 6 | 33 |
| 9 |
|
Newell's Old Boys II | 22 | 8 | 8 | 6 | 28:25 | 3 | 32 |
| 10 |
|
Atlético Tucumán II | 22 | 7 | 9 | 6 | 26:23 | 3 | 30 |
| 11 |
|
Vélez Sarsfield II | 21 | 7 | 9 | 5 | 26:24 | 2 | 30 |
| 12 |
|
Godoy Cruz II | 22 | 7 | 9 | 6 | 24:27 | -3 | 30 |
| 13 |
|
Sarmiento de Junín II | 22 | 7 | 7 | 8 | 30:34 | -4 | 28 |
| 14 |
|
River Plate II | 22 | 9 | 1 | 12 | 27:31 | -4 | 28 |
| 15 |
|
Banfield II | 22 | 8 | 4 | 10 | 25:32 | -7 | 28 |
| 16 |
|
Talleres de Córdoba II | 21 | 6 | 9 | 6 | 21:22 | -1 | 27 |
| 17 |
|
Independiente II | 22 | 6 | 9 | 7 | 18:21 | -3 | 27 |
| 18 |
|
Huracán II | 22 | 8 | 3 | 11 | 20:24 | -4 | 27 |
| 19 |
|
San Lorenzo II | 22 | 6 | 8 | 8 | 24:28 | -4 | 26 |
| 20 |
|
Arsenal de Sarandí II | 22 | 6 | 8 | 8 | 19:23 | -4 | 26 |
| 21 |
|
Defensa y Justicia II | 22 | 6 | 8 | 8 | 25:33 | -8 | 26 |
| 22 |
|
Aldosivi II | 22 | 7 | 3 | 12 | 22:30 | -8 | 24 |
| 23 |
|
Patronato de Paraná II | 22 | 6 | 5 | 11 | 26:38 | -12 | 23 |
| 24 |
|
Racing Club II | 22 | 4 | 8 | 10 | 23:33 | -10 | 20 |
| 25 |
|
Central Córdoba SdE II | 22 | 5 | 4 | 13 | 20:33 | -13 | 19 |
| 26 |
|
Unión de Santa Fe II | 22 | 3 | 10 | 9 | 18:32 | -14 | 19 |
