| 1. Ronde | 05.09.2021 | Salamanca CF UDS | - | CD Móstoles URJC | 1:0 | ||||
| 2. Ronde | 12.09.2021 | CD Móstoles URJC | - | Pontevedra CF | 2:2 |  |
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| 3. Ronde | 19.09.2021 | SD Compostela | - | CD Móstoles URJC | 3:1 | |
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| 9. Ronde | 31.10.2021 | CD Móstoles URJC | - | UD Llanera | 2:0 | ||||
| 10. Ronde | 07.11.2021 | Gimnástica Segoviana | - | CD Móstoles URJC | 0:1 | ||||
| 11. Ronde | 14.11.2021 | CD Móstoles URJC | - | Coruxo FC | 2:0 | ||||
| 12. Ronde | 21.11.2021 | Unión Adarve | - | CD Móstoles URJC | 1:0 | ||||
| 13. Ronde | 28.11.2021 | CD Móstoles URJC | - | CDA Navalcarnero | 0:1 | |
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| 14. Ronde | 05.12.2021 | Real Avilés | - | CD Móstoles URJC | 0:1 |  |
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| 15. Ronde | 12.12.2021 | CD Móstoles URJC | - | Arosa SC | 1:2 | ||||
| 16. Ronde | 18.12.2021 | UP Langreo | - | CD Móstoles URJC | 1:0 |
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