| 1. Ronde | 05.09.2021 | CD Cayón | - | AD San Juan | 0:2 | ||||
| 2. Ronde | 11.09.2021 | AD San Juan | - | Rayo Cantabria | 0:0 | ||||
| 3. Ronde | 19.09.2021 | Sestao River | - | AD San Juan | 2:1 |  |
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| 4. Ronde | 25.09.2021 | AD San Juan | - | CA Osasuna B | 0:2 | |
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| 6. Ronde | 09.10.2021 | AD San Juan | - | UD Logroñés Promesas | 1:2 | ||||
| 8. Ronde | 23.10.2021 | AD San Juan | - | CD Izarra | 0:1 | ||||
| 9. Ronde | 30.10.2021 | CD Tropezón | - | AD San Juan | 3:4 | ||||
| 10. Ronde | 06.11.2021 | AD San Juan | - | CD Laredo | 2:0 | ||||
| 11. Ronde | 14.11.2021 | Real Sociedad C | - | AD San Juan | 2:1 | ||||
| 12. Ronde | 20.11.2021 | AD San Juan | - | Náxara CD | 2:1 | ||||
| 14. Ronde | 05.12.2021 | Burgos Promesas | - | AD San Juan | 1:1 | ||||
| 15. Ronde | 11.12.2021 | AD San Juan | - | Racing Rioja CF | 1:0 | ||||
| 16. Ronde | 18.12.2021 | CF Ardoi | - | AD San Juan | 0:0 | ||||
| 17. Ronde | 08.01.2022 | AD San Juan | - | Peña Sport FC | 2:1 | ||||
| 18. Ronde | 23.01.2022 | AD San Juan | - | CD Cayón | 0:1 | ||||
| 29. Ronde | 10.04.2022 | Náxara CD | - | AD San Juan | 0:3 | ||||
| 31. Ronde | 23.04.2022 | AD San Juan | - | Burgos Promesas | 0:1 |
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