| 1. Ronde | 18.09.2021 | CF América [] | - | Cruz Azul [] | 4:2 | ||||
| 2. Ronde | 25.09.2021 | Gallos Blancos [] | - | CF América [] | 2:3 | ||||
| 3. Ronde | 20.10.2021 | CF América [] | - | Pumas UNAM [] | 3:2 |  |
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| 6. Ronde | 23.10.2021 | Cruz Azul [] | - | CF América [] | 2:2 | ||||
| 10. Ronde | 20.11.2021 | FC Juárez [] | - | CF América [] | 1:2 |
Mexico