| 1. Ronde | 08.01.2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 2:0 | ||||
| 2. Ronde | 15.01.2022 | CF Monterrey [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 3. Ronde | 22.01.2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
| 4. Ronde | 29.01.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:0 | ||||
| 9. Ronde | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
| 15. Ronde | 30.03.2022 | Deportivo Guadalajara [] | - | CF Monterrey [] | 4:1 | ||||
| 14. Ronde | 09.04.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 16. Ronde | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 17. Ronde | 30.04.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 | ||||
| 18. Ronde | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
Mexico