| 1. Ronde | 13.09.2020 | Real Oviedo | - | FC Cartagena | 0:0 | ||||
| 2. Ronde | 19.09.2020 | CD Mirandés | - | Real Oviedo | 1:1 | ||||
| 3. Ronde | 27.09.2020 | Real Oviedo | - | Espanyol | 0:2 | ||||
| 4. Ronde | 03.10.2020 | Albacete | - | Real Oviedo | 1:1 | ||||
| 6. Ronde | 18.10.2020 | Girona FC | - | Real Oviedo | 1:0 | ||||
| 7. Ronde | 22.10.2020 | Real Oviedo | - | Rayo Vallecano | 0:0 | ||||
| 8. Ronde | 25.10.2020 | CD Leganés | - | Real Oviedo | 2:1 | ||||
| 9. Ronde | 28.10.2020 | Real Oviedo | - | UD Logroñés | 2:3 | ||||
| 10. Ronde | 31.10.2020 | UD Las Palmas | - | Real Oviedo | 1:2 | ||||
| 15. Ronde | 30.11.2020 | Real Oviedo | - | UD Almería | 1:2 | ||||
| 19. Ronde | 18.12.2020 | SD Ponferradina | - | Real Oviedo | 1:0 | ||||
| 20. Ronde | 03.01.2021 | Real Oviedo | - | RCD Mallorca | 2:2 | ||||
| 25. Ronde | 15.02.2021 | Real Oviedo | - | CD Lugo | 3:1 | ||||
| 40. Ronde | 20.05.2021 | Rayo Vallecano | - | Real Oviedo | 4:1 | ||||
| 41. Ronde | 24.05.2021 | Real Oviedo | - | CD Mirandés | 1:1 | ||||
| 42. Ronde | 29.05.2021 | CD Tenerife | - | Real Oviedo | 2:2 |
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