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| 04.04.2022 | 16:00 | KV Oostende II | - | Lierse Kempenzonen II | 5:2 | |
| 19:30 | SK Beveren II | - | K Beerschot VA II | 0:5 | ||
| 20:00 | Lommel SK II | - | Royal Excel Mouscron II | 3:1 | ||
| 20:00 | Union St. Gilloise II | - | RFC Seraing II | 0:1 | ||
| 20:00 | KVC Westerlo II | - | KV Kortrijk II | 1:2 | ||
| 20:00 | Excelsior Virton II | - | KAS Eupen II | 1:2 | ||
| 20:30 | RWDM Brussels FC II | - | SK Deinze II | 0:1 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
K Beerschot VA II | 24 | 18 | 4 | 2 | 64:20 | 44 | 58 |
| 2 |
|
KAS Eupen II | 24 | 17 | 3 | 4 | 58:30 | 28 | 54 |
| 3 |
|
KV Oostende II | 24 | 14 | 7 | 3 | 59:29 | 30 | 49 |
| 4 |
|
Excelsior Virton II | 24 | 12 | 2 | 10 | 54:61 | -7 | 38 |
| 5 |
|
Royal Excel Mouscron II | 24 | 11 | 4 | 9 | 47:30 | 17 | 37 |
| 6 |
|
SK Beveren II | 24 | 11 | 2 | 11 | 40:33 | 7 | 35 |
| 7 |
|
Union St. Gilloise II | 24 | 10 | 5 | 9 | 34:27 | 7 | 35 |
| 8 |
|
RWDM Brussels FC II | 24 | 11 | 2 | 11 | 47:46 | 1 | 35 |
| 9 |
|
RFC Seraing II | 24 | 10 | 2 | 12 | 36:38 | -2 | 32 |
| 10 |
|
KVC Westerlo II | 24 | 8 | 2 | 14 | 35:44 | -9 | 26 |
| 11 |
|
Lierse Kempenzonen II | 24 | 7 | 4 | 13 | 29:58 | -29 | 25 |
| 12 |
|
SK Deinze II | 24 | 6 | 3 | 15 | 25:52 | -27 | 21 |
| 13 |
|
Lommel SK II | 24 | 5 | 4 | 15 | 26:58 | -32 | 19 |
| 14 |
|
KV Kortrijk II | 24 | 3 | 6 | 15 | 31:59 | -28 | 15 |
| Promotie |
