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| U | Floresta - CE | - | Ferroviário - CE | 0:0 (0:0) | ||
| R | Ferroviário - CE | - | Floresta - CE | 3:4 (0:0, 1:1, 1:1) d.p. | ||
| U: 27.10.2021 02:30 | R: 03.11.2021 01:30 | Winnaars: Floresta - CE | ||||
| U | Botafogo - PB | - | Vitória - BA | 1:1 (0:1) | ||
| R | Vitória - BA | - | Botafogo - PB | 5:6 (2:0, 2:2) d.p. | ||
| U: 27.10.2021 02:30 | R: 19.11.2021 01:30 | Winnaars: Botafogo - PB | ||||
| U | Sousa - PB | - | ABC - RN | 3:0 (2:0) | ||
| R | ABC - RN | - | Sousa - PB | 2:1 (0:0) | ||
| U: 27.10.2021 20:30 | R: 10.11.2021 00:30 | Winnaars: Sousa - PB | ||||
| U | Moto Club - MA | - | CR Brasil - AL | 2:1 (1:1) | ||
| R | CR Brasil - AL | - | Moto Club - MA | 2:0 (1:0) | ||
| U: 30.10.2021 20:30 | R: 18.11.2021 23:00 | Winnaars: CR Brasil - AL | ||||
