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| U | Internacional | - | Atlético Mineiro | 0:0 (0:0) | ||
| R | Atlético Mineiro | - | Internacional | 0:1 (0:0) | ||
| U: 31.10.2021 20:00 | R: 07.11.2021 15:00 | Winnaars: Internacional | ||||
| U | São Paulo FC | - | Flamengo RJ | 1:0 (1:0) | ||
| R | Flamengo RJ | - | São Paulo FC | 1:1 (0:1) | ||
| U: 01.11.2021 19:00 | R: 05.11.2021 19:30 | Winnaars: São Paulo FC | ||||
