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| U | La Equidad | - | Deportivo Cali | 1:1 (0:1) | ||
| R | Deportivo Cali | - | La Equidad | 0:1 (0:0) | ||
| U: 21.11.2020 23:30 | R: 28.11.2020 23:30 | Winnaars: La Equidad | ||||
| U | América de Cali | - | Atlético Nacional | 1:2 (1:1) | ||
| R | Atlético Nacional | - | América de Cali | 0:3 (0:2) | ||
| U: 22.11.2020 02:00 | R: 29.11.2020 02:00 | Winnaars: América de Cali | ||||
| U | Atlético Junior | - | Deportes Tolima | 1:0 (1:0) | ||
| R | Deportes Tolima | - | Atlético Junior | 0:1 (0:0) | ||
| U: 23.11.2020 00:05 | R: 30.11.2020 02:00 | Winnaars: Atlético Junior | ||||
| U | Deportivo Pasto | - | Santa Fe | 1:0 (1:0) | ||
| R | Santa Fe | - | Deportivo Pasto | 2:0 (2:0) | ||
| U: 23.11.2020 02:10 | R: 29.11.2020 23:30 | Winnaars: Santa Fe | ||||
