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| U | Toronto FC | - | Santos Laguna | 1:1 (1:1) | ||
| R | Santos Laguna | - | Toronto FC | 6:2 (2:2) | ||
| U: 29.03.2012 02:00 | R: 05.04.2012 02:00 | Winnaars: Santos Laguna | ||||
| U | CF Monterrey | - | Pumas UNAM | 3:0 (1:0) | ||
| R | Pumas UNAM | - | CF Monterrey | 1:1 (0:1) | ||
| U: 29.03.2012 04:00 | R: 05.04.2012 04:00 | Winnaars: CF Monterrey | ||||
