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| 14.05.2022 | 18:00 | AS Béziers | - | FC Nantes (CFA) | 4:2 (1:1) | |
| 18:00 | Bourges Foot 18 | - | Andrézieux-Bouthéon FC | 1:0 (0:0) | ||
| 18:00 | Le Puy Foot 43 | - | FC Chamalières | 1:0 (1:0) | ||
| 18:00 | Angers SCO II | - | Montpellier HSC (CFA) | 1:0 (1:0) | ||
| 18:00 | Trélissac FC | - | Angoulême CFC | 1:1 (0:0) | ||
| 18:00 | Vendée Les Herbiers | - | Bergerac Foot | 1:1 (0:0) | ||
| 18:30 | Moulins Yzeure Foot | - | Canet Roussillon | 1:2 (0:1) | ||
| 18:30 | Stade Montois | - | US Colomiers | 0:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Le Puy Foot 43 | 28 | 16 | 7 | 5 | 37:16 | 21 | 55 |
| 2 |
|
Bergerac Foot | 28 | 15 | 9 | 4 | 32:15 | 17 | 54 |
| 3 |
|
Bourges Foot 18 | 28 | 15 | 5 | 8 | 40:23 | 17 | 50 |
| 4 |
|
Andrézieux-Bouthéon FC | 28 | 14 | 6 | 8 | 39:27 | 12 | 48 |
| 5 |
|
Angoulême CFC | 28 | 13 | 9 | 6 | 32:22 | 10 | 48 |
| 6 |
|
AS Béziers | 28 | 12 | 8 | 8 | 41:31 | 10 | 44 |
| 7 |
|
Moulins Yzeure Foot | 28 | 10 | 10 | 8 | 29:27 | 2 | 40 |
| 8 |
|
Vendée Les Herbiers | 28 | 9 | 9 | 10 | 30:32 | -2 | 36 |
| 9 |
|
Trélissac FC | 28 | 9 | 8 | 11 | 26:26 | 0 | 35 |
| 10 |
|
Angers SCO II | 28 | 7 | 12 | 9 | 25:27 | -2 | 33 |
| 11 |
|
FC Nantes (CFA) | 28 | 8 | 9 | 11 | 30:33 | -3 | 33 |
| 12 |
|
Canet Roussillon | 28 | 13 | 5 | 10 | 29:33 | -4 | 33 |
| 13 |
|
FC Chamalières | 28 | 7 | 7 | 14 | 28:40 | -12 | 28 |
| 14 |
|
Montpellier HSC (CFA) | 28 | 7 | 6 | 15 | 31:42 | -11 | 27 |
| 15 |
|
US Colomiers | 28 | 6 | 9 | 13 | 28:40 | -12 | 27 |
| 16 |
|
Stade Montois | 28 | 1 | 5 | 22 | 20:63 | -43 | 8 |
| Promotie | |
| Degradatie |
