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| U | AE Lárissa | - | Asteras Tripolis | 0:3 (0:1) | ||
| R | Asteras Tripolis | - | AE Lárissa | 3:0 (2:0) | ||
| U: 05.01.2016 16:15 | R: 13.01.2016 16:15 | Winnaars: Asteras Tripolis | ||||
| U | Veria FC | - | AEP Iraklis FC | 0:1 (0:0) | ||
| R | AEP Iraklis FC | - | Veria FC | 1:0 (0:0) | ||
| U: 05.01.2016 18:30 | R: 13.01.2016 14:00 | Winnaars: AEP Iraklis FC | ||||
| U | Platanias Chanion | - | Atromitos | 0:0 (0:0) | ||
| R | Atromitos | - | Platanias Chanion | 2:1 (1:1) | ||
| U: 06.01.2016 14:00 | R: 12.01.2016 18:30 | Winnaars: Atromitos | ||||
| U | Ergotelis | - | Panionios GSS | 0:1 (0:1) | ||
| R | Panionios GSS | - | Ergotelis | 1:0 (1:0) | ||
| U: 06.01.2016 16:15 | R: 14.01.2016 14:00 | Winnaars: Panionios GSS | ||||
| U | Levadiakos | - | AEK Athene | 0:1 (0:1) | ||
| R | AEK Athene | - | Levadiakos | 2:0 (1:0) | ||
| U: 06.01.2016 16:15 | R: 13.01.2016 16:15 | Winnaars: AEK Athene | ||||
| U | AEL Kalloni | - | PAOK Saloniki | 2:1 (1:0) | ||
| R | PAOK Saloniki | - | AEL Kalloni | 3:0 (0:0) | ||
| U: 06.01.2016 18:30 | R: 14.01.2016 16:15 | Winnaars: PAOK Saloniki | ||||
| U | PAS Giannina | - | Panathinaikos | 1:2 (0:0) | ||
| R | Panathinaikos | - | PAS Giannina | 0:1 (0:0) | ||
| U: 07.01.2016 14:00 | R: 14.01.2016 18:30 | Winnaars: Panathinaikos | ||||
| U | AO Chania | - | Olympiakos | 1:4 (1:2) | ||
| R | Olympiakos | - | AO Chania | 6:0 (4:0) | ||
| U: 07.01.2016 16:15 | R: 13.01.2016 18:30 | Winnaars: Olympiakos | ||||
