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| 02.04.2022 | 16:00 | RFCU Luxemburg | - | Union Titus Pétange | 0:0 (0:0) | |
| 18:00 | Progrès Niedercorn | - | Swift Hesperange | 2:2 (1:0) | ||
| 03.04.2022 | 16:00 | F91 Dudelange | - | FC Differdange 03 | 1:0 (0:0) | |
| 16:00 | RM Hamm Benfica | - | CS FOLA Esch | 0:7 (0:4) | ||
| 16:00 | US Hostert | - | US Mondorf | 1:1 (1:1) | ||
| 16:00 | Jeunesse Esch | - | Etzella Ettelbruck | 5:1 (1:1) | ||
| 16:00 | FC Rodange 91 | - | UNA Strassen | 1:0 (0:0) | ||
| 16:00 | FC Wiltz 71 | - | Victoria Rosport | 1:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
F91 Dudelange | 23 | 16 | 4 | 3 | 57:21 | 36 | 52 |
| 2 |
|
Progrès Niedercorn | 23 | 14 | 5 | 4 | 58:28 | 30 | 47 |
| 3 |
|
Swift Hesperange | 23 | 13 | 5 | 5 | 46:21 | 25 | 44 |
| 4 |
|
CS FOLA Esch | 23 | 12 | 7 | 4 | 51:31 | 20 | 43 |
| 5 |
|
FC Differdange 03 | 23 | 13 | 4 | 6 | 46:27 | 19 | 43 |
| 6 |
|
RFCU Luxemburg | 23 | 12 | 4 | 7 | 44:34 | 10 | 40 |
| 7 |
|
Jeunesse Esch | 23 | 11 | 4 | 8 | 36:24 | 12 | 37 |
| 8 |
|
UNA Strassen | 23 | 10 | 7 | 6 | 36:25 | 11 | 37 |
| 9 |
|
Victoria Rosport | 23 | 8 | 7 | 8 | 40:41 | -1 | 31 |
| 10 |
|
Union Titus Pétange | 23 | 9 | 1 | 13 | 34:34 | 0 | 28 |
| 11 |
|
Etzella Ettelbruck | 23 | 9 | 0 | 14 | 37:59 | -22 | 27 |
| 12 |
|
US Mondorf | 23 | 7 | 5 | 11 | 27:35 | -8 | 26 |
| 13 |
|
US Hostert | 23 | 7 | 4 | 12 | 34:48 | -14 | 25 |
| 14 |
|
FC Wiltz 71 | 23 | 7 | 3 | 13 | 29:42 | -13 | 24 |
| 15 |
|
FC Rodange 91 | 23 | 4 | 1 | 18 | 18:59 | -41 | 13 |
| 16 |
|
RM Hamm Benfica | 23 | 1 | 1 | 21 | 11:75 | -64 | 4 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
