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| U | CF América | - | Deportivo Guadalajara | 3:1 (1:0) | ||
| R | Deportivo Guadalajara | - | CF América | 3:3 (0:1) | ||
| U: 05.11.2022 01:00 | R: 08.11.2022 02:00 | Winnaars: CF América | ||||
| U | UANL Tigres | - | CF Monterrey | 2:1 (2:0) | ||
| R | CF Monterrey | - | UANL Tigres | 2:2 (1:1) | ||
| U: 05.11.2022 03:06 | R: 08.11.2022 04:06 | Winnaars: UANL Tigres | ||||
