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| U | Cruz Azul | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| R | Deportivo Guadalajara | - | Cruz Azul | 1:1 (1:0) | ||
| U: 27.10.2022 23:00 | R: 30.10.2022 23:40 | Winnaars: Deportivo Guadalajara | ||||
| U | CF Pachuca | - | CF Monterrey | 2:1 (0:0) | ||
| R | CF Monterrey | - | CF Pachuca | 4:0 (1:0) | ||
| U: 29.10.2022 00:05 | R: 01.11.2022 04:00 | Winnaars: CF Monterrey | ||||
| U | Deportivo Toluca | - | UANL Tigres | 0:4 (0:3) | ||
| R | UANL Tigres | - | Deportivo Toluca | 5:0 (2:0) | ||
| U: 29.10.2022 02:00 | R: 01.11.2022 02:00 | Winnaars: UANL Tigres | ||||
| U | Club Tijuana | - | CF América | 0:1 (0:1) | ||
| R | CF América | - | Club Tijuana | 2:0 (1:0) | ||
| U: 29.10.2022 04:06 | R: 01.11.2022 00:00 | Winnaars: CF América | ||||
