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| U | Leones Negros | - | Club Celaya | 0:3 (0:1) | ||
| R | Club Celaya | - | Leones Negros | 1:0 (0:0) | ||
| U: 03.05.2023 03:00 | R: 06.05.2023 03:05 | Winnaars: Club Celaya | ||||
| U | CF Monterrey II | - | Atlante | 1:1 (0:1) | ||
| R | Atlante | - | CF Monterrey II | 1:0 (0:0) | ||
| U: 04.05.2023 03:00 | R: 06.05.2023 20:00 | Winnaars: Atlante | ||||
| U | Coyotes de Tlaxcala | - | Tapatío | 2:2 (0:1) | ||
| R | Tapatío | - | Coyotes de Tlaxcala | 1:1 (0:0) | ||
| U: 04.05.2023 05:05 | R: 07.05.2023 01:00 | Winnaars: Tapatío | ||||
| U | Cimarrones de Sonora | - | Atlético Morelia | 1:1 (0:1) | ||
| R | Atlético Morelia | - | Cimarrones de Sonora | 1:0 (1:0) | ||
| U: 05.05.2023 05:05 | R: 08.05.2023 01:00 | Winnaars: Atlético Morelia | ||||
