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| U | Saltillo FC | - | Alacranes de Durango | 0:1 (0:0) | ||
| R | Alacranes de Durango | - | Saltillo FC | 1:0 (1:0) | ||
| U: 01.12.2021 23:00 | R: 05.12.2021 03:00 | Winnaars: Alacranes de Durango | ||||
| U | Coras de Nayarit | - | Cafetaleros de Chiapas | 0:2 (0:1) | ||
| R | Cafetaleros de Chiapas | - | Coras de Nayarit | 3:3 (1:1) | ||
| U: 02.12.2021 04:30 | R: 05.12.2021 02:00 | Winnaars: Cafetaleros de Chiapas | ||||
| U | Yalmakan FC | - | Inter Playa | 0:2 (0:0) | ||
| R | Inter Playa | - | Yalmakan FC | 3:1 (1:0) | ||
| U: 02.12.2021 21:00 | R: 05.12.2021 21:00 | Winnaars: Inter Playa | ||||
