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| 15.10.2022 | 16:00 | Cruz Azul | - | Deportivo Toluca | 3:2 (0:1) | |
| 16:00 | Puebla FC | - | Club Necaxa | 2:2 (1:1) | ||
| 16:00 | Atlético San Luis | - | Mazatlán FC | 1:1 (0:1) | ||
| 17:00 | FC Juárez | - | CF Pachuca | 0:2 (0:0) | ||
| 19:00 | Club Tijuana | - | Atlas Guadalajara | 0:2 (0:1) | ||
| 23:00 | CF América | - | Pumas UNAM | 0:1 (0:0) | ||
| 23:00 | Deportivo Guadalajara | - | UANL Tigres | 3:1 (0:1) | ||
| 23:00 | CF Monterrey | - | Santos Laguna | 1:2 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 15 | 8 | 2 | 5 | 40:28 | 12 | 26 |
| 2 |
|
Club Necaxa | 15 | 7 | 4 | 4 | 37:24 | 13 | 25 |
| 3 |
|
Cruz Azul | 15 | 7 | 4 | 4 | 35:24 | 11 | 25 |
| 4 |
|
CF América | 15 | 6 | 4 | 5 | 27:26 | 1 | 22 |
| 5 |
|
CF Pachuca | 15 | 7 | 1 | 7 | 24:23 | 1 | 22 |
| 6 |
|
Pumas UNAM | 15 | 6 | 4 | 5 | 18:20 | -2 | 22 |
| 7 |
|
Gallos Blancos | 15 | 6 | 2 | 7 | 18:29 | -11 | 20 |
| 8 |
|
FC Juárez | 16 | 4 | 6 | 6 | 21:27 | -6 | 18 |
| 9 |
|
Puebla FC | 15 | 2 | 3 | 10 | 20:39 | -19 | 9 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 15 | 11 | 3 | 1 | 32:15 | 17 | 36 |
| 2 |
|
Santos Laguna | 15 | 11 | 1 | 3 | 30:12 | 18 | 34 |
| 3 |
|
CF Monterrey | 15 | 8 | 2 | 5 | 34:20 | 14 | 26 |
| 4 |
|
Atlas Guadalajara | 15 | 7 | 3 | 5 | 22:16 | 6 | 24 |
| 5 |
|
Mazatlán FC | 15 | 7 | 2 | 6 | 19:24 | -5 | 23 |
| 6 |
|
UANL Tigres | 15 | 6 | 1 | 8 | 19:21 | -2 | 19 |
| 7 |
|
Atlético San Luis | 16 | 4 | 4 | 8 | 22:31 | -9 | 16 |
| 8 |
|
Club Tijuana | 15 | 4 | 2 | 9 | 16:28 | -12 | 14 |
| 9 |
|
Club León | 15 | 0 | 2 | 13 | 19:46 | -27 | 2 |
| Play-offs | |
| Play-offs |
