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| U | Gallos Blancos | - | CF América | 0:1 (0:1) | ||
| R | CF América | - | Gallos Blancos | 2:1 (0:0) | ||
| U: 03.05.2023 17:00 | R: 06.05.2023 17:00 | Winnaars: CF América | ||||
| U | Puebla FC | - | Atlas Guadalajara | 1:3 (1:2) | ||
| R | Atlas Guadalajara | - | Puebla FC | 3:2 (1:0) | ||
| U: 03.05.2023 18:00 | R: 06.05.2023 17:00 | Winnaars: Atlas Guadalajara | ||||
| U | Santos Laguna | - | Deportivo Guadalajara | 3:4 (2:3) | ||
| R | Deportivo Guadalajara | - | Santos Laguna | 2:2 (0:1) | ||
| U: 03.05.2023 19:00 | R: 06.05.2023 19:30 | Winnaars: Deportivo Guadalajara | ||||
| U | UANL Tigres | - | Deportivo Toluca | 1:0 (1:0) | ||
| R | Deportivo Toluca | - | UANL Tigres | 2:1 (0:0) | ||
| U: 04.05.2023 17:00 | R: 07.05.2023 16:00 | Winnaars: UANL Tigres | ||||
