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| 20.11.2021 | 13:00 | FK Skopje | - | Makedonija GP | 1:2 (0:0) | |
| 21.11.2021 | 13:00 | Akademija Pandev | - | GFK Tikvesh | 3:2 (1:1) | |
| 13:00 | FK Borec | - | FK Renova | 1:4 (0:3) | ||
| 13:00 | KF Shkupi | - | FK Pelister | 5:0 (3:0) | ||
| 13:00 | KF Shkëndija 79 | - | FK Bregalnica Štip | 1:0 (0:0) | ||
| 13:00 | FC Struga | - | FK Rabotnički | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 14 | 10 | 2 | 2 | 32:9 | 23 | 32 |
| 2 |
|
Akademija Pandev | 14 | 8 | 4 | 2 | 24:13 | 11 | 28 |
| 3 |
|
FK Renova | 14 | 7 | 4 | 3 | 23:12 | 11 | 25 |
| 4 |
|
KF Shkëndija 79 | 14 | 6 | 6 | 2 | 22:11 | 11 | 24 |
| 5 |
|
FC Struga | 14 | 5 | 7 | 2 | 13:9 | 4 | 22 |
| 6 |
|
FK Bregalnica Štip | 14 | 6 | 4 | 4 | 21:21 | 0 | 22 |
| 7 |
|
Makedonija GP | 14 | 6 | 2 | 6 | 19:26 | -7 | 20 |
| 8 |
|
FK Rabotnički | 14 | 5 | 3 | 6 | 10:14 | -4 | 18 |
| 9 |
|
FK Skopje | 14 | 4 | 4 | 6 | 11:18 | -7 | 16 |
| 10 |
|
GFK Tikvesh | 14 | 2 | 4 | 8 | 12:19 | -7 | 10 |
| 11 |
|
FK Borec | 14 | 2 | 2 | 10 | 11:27 | -16 | 8 |
| 12 |
|
FK Pelister | 14 | 0 | 4 | 10 | 4:23 | -19 | 4 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
