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| 19.02.2022 | 14:00 | FK Borec | - | KF Shkëndija 79 | 0:3 (0:1) | |
| 20.02.2022 | 14:00 | Akademija Pandev | - | FK Skopje | 5:0 (3:0) | |
| 14:00 | FK Rabotnički | - | KF Shkupi | 0:1 (0:0) | ||
| 14:00 | FK Renova | - | Makedonija GP | 0:1 (0:1) | ||
| 14:00 | FC Struga | - | FK Bregalnica Štip | 1:1 (0:0) | ||
| 14:00 | GFK Tikvesh | - | FK Pelister | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 20 | 15 | 3 | 2 | 46:12 | 34 | 48 |
| 2 |
|
KF Shkëndija 79 | 20 | 11 | 7 | 2 | 34:15 | 19 | 40 |
| 3 |
|
Akademija Pandev | 20 | 11 | 5 | 4 | 34:20 | 14 | 38 |
| 4 |
|
Makedonija GP | 20 | 10 | 3 | 7 | 29:31 | -2 | 33 |
| 5 |
|
FK Renova | 20 | 8 | 6 | 6 | 27:18 | 9 | 30 |
| 6 |
|
FK Bregalnica Štip | 20 | 8 | 6 | 6 | 29:28 | 1 | 30 |
| 7 |
|
FC Struga | 20 | 6 | 9 | 5 | 16:18 | -2 | 27 |
| 8 |
|
FK Rabotnički | 20 | 7 | 4 | 9 | 15:20 | -5 | 25 |
| 9 |
|
FK Skopje | 20 | 5 | 6 | 9 | 14:28 | -14 | 21 |
| 10 |
|
GFK Tikvesh | 20 | 4 | 6 | 10 | 17:24 | -7 | 18 |
| 11 |
|
FK Borec | 20 | 3 | 4 | 13 | 17:38 | -21 | 13 |
| 12 |
|
FK Pelister | 20 | 0 | 5 | 15 | 6:32 | -26 | 5 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
