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| 18.03.2022 | 15:00 | FC Struga | - | KF Shkupi | 1:3 (1:1) | |
| 19.03.2022 | 15:00 | FK Renova | - | FK Rabotnički | 2:1 (0:0) | |
| 15:00 | FK Pelister | - | FK Bregalnica Štip | 2:0 (1:0) | ||
| 15:00 | FK Borec | - | Makedonija GP | 0:1 (0:1) | ||
| 15:00 | FK Skopje | - | KF Shkëndija 79 | 0:2 (0:1) | ||
| 15:00 | GFK Tikvesh | - | Akademija Pandev | 1:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 24 | 18 | 4 | 2 | 54:15 | 39 | 58 |
| 2 |
|
Akademija Pandev | 24 | 14 | 6 | 4 | 42:21 | 21 | 48 |
| 3 |
|
KF Shkëndija 79 | 24 | 13 | 8 | 3 | 39:18 | 21 | 47 |
| 4 |
|
Makedonija GP | 24 | 13 | 4 | 7 | 36:34 | 2 | 43 |
| 5 |
|
FK Renova | 24 | 9 | 9 | 6 | 30:20 | 10 | 36 |
| 6 |
|
FK Bregalnica Štip | 24 | 10 | 6 | 8 | 35:33 | 2 | 36 |
| 7 |
|
FK Rabotnički | 24 | 9 | 4 | 11 | 19:25 | -6 | 31 |
| 8 |
|
FC Struga | 24 | 7 | 9 | 8 | 19:25 | -6 | 30 |
| 9 |
|
FK Skopje | 24 | 5 | 7 | 12 | 15:35 | -20 | 22 |
| 10 |
|
GFK Tikvesh | 24 | 5 | 6 | 13 | 24:31 | -7 | 21 |
| 11 |
|
FK Borec | 24 | 3 | 4 | 17 | 17:48 | -31 | 13 |
| 12 |
|
FK Pelister | 24 | 1 | 7 | 16 | 10:35 | -25 | 10 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
