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| 16.04.2022 | 16:00 | Makedonija GP | - | FK Rabotnički | 1:0 (1:0) | |
| 16:00 | FK Pelister | - | KF Shkupi | 0:1 (0:0) | ||
| 16:00 | FK Borec | - | FC Struga | 2:0 (0:0) | ||
| 17.04.2022 | 16:00 | FK Bregalnica Štip | - | KF Shkëndija 79 | 0:0 (0:0) | |
| 16:00 | FK Renova | - | Akademija Pandev | 0:1 (0:0) | ||
| 16:00 | FK Skopje | - | GFK Tikvesh | 1:2 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 28 | 21 | 5 | 2 | 59:16 | 43 | 68 |
| 2 |
|
Akademija Pandev | 28 | 16 | 7 | 5 | 47:24 | 23 | 55 |
| 3 |
|
KF Shkëndija 79 | 28 | 14 | 11 | 3 | 42:19 | 23 | 53 |
| 4 |
|
Makedonija GP | 28 | 16 | 5 | 7 | 41:35 | 6 | 53 |
| 5 |
|
FK Bregalnica Štip | 28 | 10 | 9 | 9 | 38:39 | -1 | 39 |
| 6 |
|
FK Renova | 28 | 9 | 11 | 8 | 33:25 | 8 | 38 |
| 7 |
|
FK Rabotnički | 28 | 11 | 4 | 13 | 24:29 | -5 | 37 |
| 8 |
|
FC Struga | 28 | 9 | 9 | 10 | 23:30 | -7 | 36 |
| 9 |
|
GFK Tikvesh | 28 | 7 | 6 | 15 | 28:34 | -6 | 27 |
| 10 |
|
FK Skopje | 28 | 6 | 8 | 14 | 18:39 | -21 | 26 |
| 11 |
|
FK Borec | 28 | 4 | 6 | 18 | 21:52 | -31 | 18 |
| 12 |
|
FK Pelister | 28 | 1 | 7 | 20 | 10:42 | -32 | 10 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
