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| 02.10.2021 | 15:00 | FK Bregalnica Štip | - | FC Struga | 1:0 (1:0) | |
| 15:00 | FK Pelister | - | GFK Tikvesh | 0:0 (0:0) | ||
| 15:00 | FK Skopje | - | Akademija Pandev | 0:0 (0:0) | ||
| 15:00 | KF Shkëndija 79 | - | FK Borec | 3:0 (3:0) | ||
| 15:00 | Makedonija GP | - | FK Renova | 1:1 (0:0) | ||
| 03.10.2021 | 15:00 | KF Shkupi | - | FK Rabotnički | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 9 | 6 | 2 | 1 | 18:6 | 12 | 20 |
| 2 |
|
FK Renova | 9 | 5 | 3 | 1 | 16:8 | 8 | 18 |
| 3 |
|
Akademija Pandev | 9 | 4 | 3 | 2 | 14:9 | 5 | 15 |
| 4 |
|
FK Rabotnički | 9 | 4 | 3 | 2 | 9:7 | 2 | 15 |
| 5 |
|
KF Shkëndija 79 | 9 | 3 | 5 | 1 | 16:8 | 8 | 14 |
| 6 |
|
FC Struga | 9 | 3 | 4 | 2 | 9:7 | 2 | 13 |
| 7 |
|
FK Bregalnica Štip | 9 | 3 | 4 | 2 | 12:13 | -1 | 13 |
| 8 |
|
Makedonija GP | 9 | 3 | 1 | 5 | 11:19 | -8 | 10 |
| 9 |
|
FK Skopje | 9 | 2 | 3 | 4 | 6:13 | -7 | 9 |
| 10 |
|
FK Borec | 9 | 2 | 1 | 6 | 7:17 | -10 | 7 |
| 11 |
|
GFK Tikvesh | 9 | 1 | 3 | 5 | 6:11 | -5 | 6 |
| 12 |
|
FK Pelister | 9 | 0 | 4 | 5 | 4:10 | -6 | 4 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
