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| 01.05.2000 | 20:00 | Dordrecht '90 | - | FC Groningen | 1:3 (1:1) | |
| 20:00 | SBV Eindhoven | - | TOP Oss | 7:2 (3:0) | ||
| 20:00 | SBV Excelsior | - | NAC Breda | 2:3 (2:2) | ||
| 20:00 | HFC Haarlem | - | BV Emmen | 2:4 (1:3) | ||
| 20:00 | Helmond Sport | - | Heracles Almelo | 1:1 (1:1) | ||
| 20:00 | RBC Roosendaal | - | Telstar | 3:2 (2:0) | ||
| 20:00 | BV Veendam | - | ADO Den Haag | 4:4 (1:1) | ||
| 20:00 | FC Volendam | - | Go Ahead Eagles | 2:2 (2:0) | ||
| 20:00 | FC Zwolle | - | VVV | 4:0 (3:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
NAC Breda | 32 | 25 | 1 | 6 | 78:34 | 44 | 76 |
| 2 |
|
FC Zwolle | 32 | 21 | 7 | 4 | 84:37 | 47 | 70 |
| 3 |
|
FC Groningen | 32 | 21 | 5 | 6 | 74:31 | 43 | 68 |
| 4 |
|
BV Emmen | 32 | 18 | 4 | 10 | 50:39 | 11 | 58 |
| 5 |
|
RBC Roosendaal | 32 | 17 | 5 | 10 | 63:45 | 18 | 56 |
| 6 |
|
SBV Excelsior | 32 | 16 | 5 | 11 | 64:46 | 18 | 53 |
| 7 |
|
Heracles Almelo | 32 | 13 | 7 | 12 | 38:37 | 1 | 46 |
| 8 |
|
SBV Eindhoven | 32 | 14 | 3 | 15 | 44:57 | -13 | 45 |
| 9 |
|
Dordrecht '90 | 32 | 10 | 9 | 13 | 50:56 | -6 | 39 |
| 10 |
|
ADO Den Haag | 32 | 11 | 6 | 15 | 36:51 | -15 | 39 |
| 11 |
|
BV Veendam | 32 | 9 | 10 | 13 | 46:59 | -13 | 37 |
| 12 |
|
Helmond Sport | 32 | 11 | 3 | 18 | 40:54 | -14 | 36 |
| 13 |
|
Go Ahead Eagles | 32 | 9 | 8 | 15 | 54:55 | -1 | 35 |
| 14 |
|
VVV | 32 | 8 | 10 | 14 | 37:60 | -23 | 34 |
| 15 |
|
Telstar | 32 | 10 | 3 | 19 | 39:55 | -16 | 33 |
| 16 |
|
HFC Haarlem | 32 | 9 | 4 | 19 | 51:67 | -16 | 31 |
| 17 |
|
FC Volendam | 32 | 8 | 7 | 17 | 38:68 | -30 | 31 |
| 18 |
|
TOP Oss | 32 | 8 | 3 | 21 | 33:68 | -35 | 27 |
