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| 07.11.2006 | 20:00 | De Graafschap | - | FC Emmen | 1:0 (0:0) | |
| 20:00 | MVV Maastricht | - | Stormvogels Telstar | 3:1 (1:1) | ||
| 20:00 | Go Ahead Eagles | - | SBV Excelsior | 2:0 (0:0) | ||
| 20:00 | RBC Roosendaal | - | FC Eindhoven | 4:0 (2:0) | ||
| 20:00 | Be Quick '28 | - | Willem II | 2:5 (2:2) | ||
| 20:45 | FC Groningen | - | NAC Breda | 1:3 (1:2) | ||
| 08.11.2006 | 20:00 | Achilles'29 | - | Sparta Rotterdam | 0:4 (0:0) | |
| 20:00 | AZ Alkmaar | - | Meerssen | 10:1 (4:0) | ||
| 20:00 | FC Twente | - | NEC Nijmegen | 3:1 (2:1) | ||
| 20:00 | Roda JC Kerkrade | - | ASWH | 5:0 (4:0) | ||
| 20:45 | RKC Waalwijk | - | Feyenoord | 3:2 (0:0, 1:1) n.v. | ||
| 09.11.2006 | 20:00 | FC Utrecht | - | Rijnsburgse Boys | 5:0 (1:0) | |
| 20:00 | HFC Haarlem | - | FC Den Bosch | 1:0 (0:0) | ||
| 20:00 | Vitesse | - | PSV | 0:4 (0:2) | ||
| 20:00 | Jong AZ Alkmaar | - | SC Genemuiden | 8:1 (5:0) | ||
| 20:45 | AFC Ajax | - | ADO Den Haag | 2:0 (1:0) |
