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| 16.04.2022 | 15:00 | FC Black Stars Basel | - | BSC Young Boys II | 1:2 (1:1) | |
| 16:00 | SC YF/Juventus Zürich | - | FC Biel/Bienne | 1:1 (0:1) | ||
| 16:00 | FC Bavois | - | AC Bellinzona | 0:1 (0:1) | ||
| 16:00 | FC Breitenrain Bern | - | FC Sion II | 2:0 (1:0) | ||
| 16:00 | FC Zürich II | - | Etoile Carouge FC | 1:1 (1:0) | ||
| 16:00 | SC Brühl | - | FC Basel II | 0:3 (0:1) | ||
| 16:00 | SC Cham | - | FC Chiasso | 2:4 (2:2) | ||
| 17:00 | FC Rapperswil-Jona | - | Stade Nyonnais | 1:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Breitenrain Bern | 28 | 19 | 7 | 2 | 56:25 | 31 | 64 |
| 2 |
|
AC Bellinzona | 28 | 18 | 5 | 5 | 54:28 | 26 | 59 |
| 3 |
|
Stade Nyonnais | 28 | 15 | 6 | 7 | 63:40 | 23 | 51 |
| 4 |
|
FC Chiasso | 28 | 14 | 9 | 5 | 51:30 | 21 | 51 |
| 5 |
|
FC Zürich II | 28 | 11 | 10 | 7 | 43:30 | 13 | 43 |
| 6 |
|
FC Bavois | 28 | 12 | 6 | 10 | 43:39 | 4 | 42 |
| 7 |
|
SC Cham | 28 | 10 | 9 | 9 | 46:47 | -1 | 39 |
| 8 |
|
Etoile Carouge FC | 28 | 9 | 11 | 8 | 33:35 | -2 | 38 |
| 9 |
|
BSC Young Boys II | 28 | 10 | 7 | 11 | 46:47 | -1 | 37 |
| 10 |
|
FC Rapperswil-Jona | 28 | 9 | 9 | 10 | 35:39 | -4 | 36 |
| 11 |
|
FC Biel/Bienne | 28 | 8 | 7 | 13 | 40:46 | -6 | 31 |
| 12 |
|
FC Black Stars Basel | 28 | 7 | 8 | 13 | 29:46 | -17 | 29 |
| 13 |
|
SC YF/Juventus Zürich | 28 | 7 | 6 | 15 | 36:50 | -14 | 27 |
| 14 |
|
FC Basel II | 28 | 7 | 5 | 16 | 48:68 | -20 | 26 |
| 15 |
|
SC Brühl | 28 | 4 | 8 | 16 | 35:55 | -20 | 20 |
| 16 |
|
FC Sion II | 28 | 5 | 5 | 18 | 31:64 | -33 | 20 |
| Play-offs | |
| Play-offs | |
| Promotie en degradatie |
