| 1. Ronde | 05.02.2022 | Defensor Sporting | - | Liverpool | 0:3 |  |
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| 2. Ronde | 14.02.2022 | Peñarol | - | Defensor Sporting | 0:1 |  |
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| 3. Ronde | 19.02.2022 | Defensor Sporting | - | Montevideo City Torque | 1:3 | ||||
| 4. Ronde | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | ||||
| 6. Ronde | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 7. Ronde | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Ronde | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | |
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| 9. Ronde | 16.04.2022 | Defensor Sporting | - | Fénix | 2:1 | ||||
| 10. Ronde | 26.04.2022 | Defensor Sporting | - | Cerrito | 0:0 | |
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| 11. Ronde | 07.05.2022 | Albion | - | Defensor Sporting | 0:3 | |
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| 12. Ronde | 14.05.2022 | Defensor Sporting | - | Nacional | 0:2 | |
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| 13. Ronde | 22.05.2022 | Danubio | - | Defensor Sporting | 1:2 | |
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Uruguay