| 1. Ronde | 07.02.2023 | Defensor Sporting | - | Fénix | 1:3 |  |
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| 2. Ronde | 13.02.2023 | Montevideo Wanderers | - | Defensor Sporting | 1:1 | ||||
| 3. Ronde | 19.02.2023 | Defensor Sporting | - | La Luz | 1:0 | ||||
| 4. Ronde | 26.02.2023 | Defensor Sporting | - | Peñarol | 2:2 | |
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| 5. Ronde | 04.03.2023 | Montevideo City Torque | - | Defensor Sporting | 0:3 | |
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| 6. Ronde | 13.03.2023 | Defensor Sporting | - | Liverpool | 2:2 | ||||
| 7. Ronde | 19.03.2023 | Cerro Largo | - | Defensor Sporting | 0:3 |  |
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| 8. Ronde | 25.03.2023 | Defensor Sporting | - | Plaza Colonia | 4:0 | ||||
| 9. Ronde | 03.04.2023 | Racing | - | Defensor Sporting | 0:1 | |
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| 10. Ronde | 08.04.2023 | Defensor Sporting | - | CA Cerro | 1:1 | ||||
| 11. Ronde | 16.04.2023 | Boston River | - | Defensor Sporting | 1:0 | |
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| 12. Ronde | 23.04.2023 | Defensor Sporting | - | Deportivo Maldonado | 1:1 | ||||
| 13. Ronde | 30.04.2023 | River Plate | - | Defensor Sporting | 0:4 | |
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| 14. Ronde | 07.05.2023 | Defensor Sporting | - | Nacional | 2:2 | |
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| 15. Ronde | 14.05.2023 | Danubio | - | Defensor Sporting | 1:1 | |
Uruguay