| 2. Ronde | 15.01.2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 | ||||
| 3. Ronde | 22.01.2022 | Club Necaxa [] | - | Cruz Azul [] | 4:1 | ||||
| 7. Ronde | 19.02.2022 | FC Juárez [] | - | Cruz Azul [] | 3:1 | ||||
| 15. Ronde | 23.03.2022 | Cruz Azul [] | - | Pumas UNAM [] | 1:4 | ||||
| 16. Ronde | 23.04.2022 | Puebla FC [] | - | Cruz Azul [] | 0:2 |
Mexico