| 1. Ronde | 24.07.2021 | FC Juárez | - | Deportivo Toluca | 1:3 |  |
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| 2. Ronde | 01.08.2021 | Deportivo Toluca | - | UANL Tigres | 3:1 | |
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| 3. Ronde | 07.08.2021 | Club Tijuana | - | Deportivo Toluca | 0:2 | ||||
| 4. Ronde | 15.08.2021 | Cruz Azul | - | Deportivo Toluca | 4:0 | ||||
| 5. Ronde | 18.08.2021 | Deportivo Toluca | - | Mazatlán FC | 2:2 | ||||
| 6. Ronde | 22.08.2021 | Atlas Guadalajara | - | Deportivo Toluca | 0:0 | ||||
| 7. Ronde | 29.08.2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 | |
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| 9. Ronde | 19.09.2021 | Deportivo Toluca | - | CF América | 3:1 | ||||
| 11. Ronde | 23.09.2021 | CF Monterrey | - | Deportivo Toluca | 2:0 | ||||
| 13. Ronde | 18.10.2021 | Deportivo Guadalajara | - | Deportivo Toluca | 2:0 | ||||
| 14. Ronde | 21.10.2021 | Deportivo Toluca | - | Club Necaxa | 1:1 | ||||
| 15. Ronde | 25.10.2021 | Santos Laguna | - | Deportivo Toluca | 2:2 | |
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| 16. Ronde | 31.10.2021 | Deportivo Toluca | - | Club León | 0:0 |
Argentinië