| 20. Ronde | 26.01.2022 | Rayo Majadahonda | - | Real Valladolid B | 3:1 | ||||
| 22. Ronde | 05.02.2022 | Real Valladolid B | - | Celta de Vigo B | 1:3 | ||||
| 23. Ronde | 12.02.2022 | Inter de Madrid | - | Real Valladolid B | 2:2 | ||||
| 24. Ronde | 20.02.2022 | Real Valladolid B | - | Racing Ferrol | 1:2 | ||||
| 25. Ronde | 25.02.2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 21. Ronde | 02.03.2022 | Real Unión | - | Real Valladolid B | 2:1 | ||||
| 26. Ronde | 06.03.2022 | Real Valladolid B | - | UD Logroñés | 0:2 | ||||
| 28. Ronde | 20.03.2022 | Unionistas CF | - | Real Valladolid B | 0:0 | ||||
| 30. Ronde | 02.04.2022 | CD Tudelano | - | Real Valladolid B | 1:2 | ||||
| 31. Ronde | 10.04.2022 | Real Valladolid B | - | SD Logroñés | 2:0 | ||||
| 32. Ronde | 16.04.2022 | CD Calahorra | - | Real Valladolid B | 2:1 |  |
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| 34. Ronde | 01.05.2022 | UD SS Reyes | - | Real Valladolid B | 1:1 | ||||
| 35. Ronde | 07.05.2022 | Real Valladolid B | - | CD Badajoz | 1:0 | |
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| 36. Ronde | 15.05.2022 | Racing Santander | - | Real Valladolid B | 1:0 | ||||
| 37. Ronde | 21.05.2022 | Real Valladolid B | - | Deportivo La Coruña | 0:4 | ||||
| 38. Ronde | 28.05.2022 | Zamora CF | - | Real Valladolid B | 2:0 |
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