| 6. Ronde | 12.02.2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 5:3 | ||||
| 7. Ronde | 18.02.2022 | Club León [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 8. Ronde | 26.02.2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 | ||||
| 10. Ronde | 12.03.2022 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 2:3 | ||||
| 11. Ronde | 19.03.2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 2:1 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
| 15. Ronde | 20.04.2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 0:1 | ||||
| 16. Ronde | 23.04.2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 5:0 |
Mexico